Wikel, James H : rechercher sur Z-Library

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1

Effects of Antipsychotic Drugs onIto,INa,Isus,IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

William J. Crumb, Sean Ekins, R. Dustan Sarazan, James H. Wikel, Steven A. Wrighton, Christopher Carlson, Charles M. Beasley

Journal:

Pharmaceutical Research

Année:

2006

Langue:

english

Fichier:

PDF, 617 KB

english, 2006

2

Progress in predicting human ADME parameters in silico

Sean Ekins, Chris L Waller, Peter W Swaan, Gabriele Cruciani, Steven A Wrighton, James H Wikel

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2000

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2000

3

Application of MS-WHIM Descriptors: 1. Introduction of New Molecular Surface Properties and 2. Prediction of Binding Affinity Data

Gianpaolo Bravi, James H. Wikel

Journal:

Molecular Informatics

Année:

2000

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2000

4

Application of MS-WHIM Descriptors: 3. Prediction of Molecular Properties

Gianpaolo Bravi, James H. Wikel

Journal:

Molecular Informatics

Année:

2000

Langue:

english

Fichier:

PDF, 3.27 MB

english, 2000

5

ChemInform Abstract: Three-Dimensional Quantitative Structure—Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication.

Sean Ekins, Gregory L. Durst, Robert E. Stratford, David A. Thorner, Richard Lewis, Richard J. Loncharich, James H. Wikel

Journal:

Année:

2002

Fichier:

PDF, 25 KB

2002

6

The Curtius rearrangement in aminimides

Herman P. Benecke, James H. Wikel

Journal:

Tetrahedron Letters

Année:

1972

Langue:

english

Fichier:

PDF, 165 KB

english, 1972

7

The stevens rearrangement in aminimides

Herman P. Benecke, James H. Wikel

Journal:

Tetrahedron Letters

Année:

1971

Langue:

english

Fichier:

PDF, 242 KB

english, 1971

8

QSAR study of benzoquinolinones as inhibitors of human type 1 5-α-reductase.

James H. Wikel, Kerry G. Bemis, James E. Audia, Loretta A. McQuaid, Charles D. Jones, Pamela A. Pennington, David E. Lawhorn, Kenneth R. Hirsch, Nancy B. Stamm

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 425 KB

english, 1993

9

QSAR Study of ortho-phenylphenol leukotriene B4 receptor antagonists

James H. Wikel, Michael J. Sofia, David L. Saussy Jr., Kerry G. Bemis

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 392 KB

english, 1994

10

The use of neural networks for variable selection in QSAR

James H. Wikel, Ernst R. Dow

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 468 KB

english, 1993

11

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site

Daniel J. Sall, Stephen L. Briggs, Nickolay Y. Chirgadze, David K. Clawson, Donetta S. Gifford-Moore, Valentine J. Klimkowski, Jefferson R. McCowan, Gerald F. Smith, James H. Wikel

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 512 KB

english, 1998

12

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4″ side chain1

Jolie A. Bastian, Nickolay Chirgadze, Michael L. Denney, Donetta S. Gifford-Moore, Daniel J. Sall, Gerald F. Smith, James H. Wikel

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 316 KB

english, 1999

13

A convenient synthesis of the thieno[3,2-c]pyridine nucleus

James H. Wikel, Michael L. Denney, Robert T. Vasileff

Journal:

Journal of Heterocyclic Chemistry

Année:

1993

Fichier:

PDF, 142 KB

1993

14

Depletion of cardiac norepinephrine in rats and mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Ray W. Fuller, Richard A. Hahn, Harold D. Snoddy, James H. Wikel

Journal:

Biochemical Pharmacology

Année:

1984

Langue:

english

Fichier:

PDF, 323 KB

english, 1984

15

Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds

Takeuchi, Kumiko, Kohn, Todd J., True, Timothy A., Mais, Dale E., Wikel, James H., Utterback, Barbara G., Wyss, Virginia L., Jakubowski, Joseph A.

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 303 KB

english, 1998

16

Synthesis of s-triazole[3,4-b]benzothiazoles

Wikel, James H., Paget, Charles J.

Journal:

Journal of Organic Chemistry

Année:

1974

Langue:

english

Fichier:

PDF, 329 KB

english, 1974

17

3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex

McQuaid, Loretta A., Smith, Edward C. R., Lodge, David, Pralong, Etienne, Wikel, James H., Calligaro, David O., O'Malley, Patrick J.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 346 KB

english, 1992

18

LY249933

Holland, Donald R., Wikel, James H., Kauffman, Raymond F., Smallwood, Jeffrey K., Zimmerman, Karen M., Utterback, Barbara G., Turk, John A., Steinberg, Mitchell I.

Journal:

Journal of Cardiovascular Pharmacology

Année:

1989

Fichier:

PDF, 717 KB

1989

19

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

Doyle, Kevin, Lönn, Hans, Käck, Helena, Van de Poël, Amanda, Swallow, Steve, Gardiner, Philip, Connolly, Stephen, Root, James, Wikell, Cecilia, Dahl, Göran, Stenvall, Kristina, Johannesson, Petra

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2016

20

Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization

Sardar Pasha, Sheik Pran Babu, Sishtla, Kamakshi, Sulaiman, Rania S, Park, Bomina, Shetty, Trupti, Shah, Fenil, Fishel, Melissa L, Wikel, James H, Kelley, Mark R, Corson, Timothy W.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Année:

2018

Langue:

english

Fichier:

PDF, 3.88 MB

english, 2018